Spider can refer to:
- Domestic Spider - variant of the Hatchling Antaresian Spider in Serious Sam VR: The Last Hope.
- Domestic Spider Army - power-up in Serious Sam VR: The Last Hope.
- Hatchling Antaresian Spider - enemy in Serious Sam 3: BFE, Serious Sam VR: The Last Hope, and Serious Sam 3 VR: BFE.
- Juvenile Antaresian Spider - enemy in Serious Sam 3: BFE, Serious Sam's Bogus Detour, Serious Sam VR: The Last Hope, and Serious Sam 3 VR: BFE.
- Spider Mechanoid - enemy in Serious Sam 2.
- Spider (SS:DD) - enemy in Serious Sam: Double D and Serious Sam: Double D: XXL.
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